AI in primary care and internal medicine: only 5% of 519 health-care LLM studies used real patient-care data

Zenodo 2026 · 1 min read
Health-care LLM studies using real patient-care data
5%
Out of 519 studies in a systematic review (Bedi et al., 2025)
Message reading time with AI-drafted replies
+21.8%
Primary care physicians; response time did not drop significantly (Tai-Seale et al., 2024)
Predictive algorithms implemented in primary care
43
Systematic review with limited life-cycle evidence (Rakers et al., 2024)

Arkangel AI whitepaper: AI can support synthesis, documentation and search in primary care and internal medicine, but not replace diagnosis or treatment.

This whitepaper assesses which AI support tasks in primary care and internal medicine have enough evidence for careful consideration, which remain experimental, and what governance Latin American teams would need. It is a rapid narrative synthesis based on PubMed and targeted searches run in June and July 2026, covering longitudinal synthesis, documentation, EHR search, messaging, risk prediction and diagnostic support. It is non-peer-reviewed gray literature published by Arkangel AI, and it does not evaluate any Arkangel product.

A systematic review of 519 studies of large language models in health care found that only 5% used real patient-care data. In a study integrated into the EHR, AI-drafted patient-message replies increased physicians' reading time by 21.8%, did not significantly reduce response time and made replies 17.9% longer, and a randomized trial with 50 physicians found no significant improvement in diagnostic reasoning with access to a language model. A review of predictive algorithms in primary care identified 43 implemented tools with limited public evidence across their life cycle. Direct regional evidence is narrow, led by a Brazilian scoping review of 27 studies, and the authors position AI as reviewable support for synthesis, documentation and search rather than an independent diagnostic or therapeutic tool.

Results at a glance

The headline numbers from the paper, in plain language.

MetricValueWhat it means
Health-care LLM studies using real patient-care data5%Out of 519 studies in a systematic review (Bedi et al., 2025)
Message reading time with AI-drafted replies+21.8%Primary care physicians; response time did not drop significantly (Tai-Seale et al., 2024)
Predictive algorithms implemented in primary care43Systematic review with limited life-cycle evidence (Rakers et al., 2024)

How to cite

Katherine Monsalve, Natalia Castaño-Villegas, Jose Zea, Laura Velásquez. Supportive AI in Primary Care and Internal Medicine Evidence, Limitations, and Governance for Latin America. Zenodo. 2026. https://doi.org/10.5281/zenodo.23111917

@article{monsalve2026supportive,
  title     = {{Supportive AI in Primary Care and Internal Medicine Evidence, Limitations, and Governance for Latin America}},
  author    = {Katherine Monsalve and Natalia Castaño-Villegas and Jose Zea and Laura Velásquez},
  journal   = {Zenodo},
  year      = {2026},
  doi       = {10.5281/zenodo.23111917},
  url       = {https://doi.org/10.5281/zenodo.23111917}
}

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