Practice EBM end to end, faster
Evidence-based medicine (EBM) combines the best available evidence, your clinical expertise and the patient's values. With AI, you turn the case into a PICO question, find cited evidence and rate its certainty with GRADE, without losing traceability.
Start with a real clinical question
Pick a question to ask Arkangel AI — we keep it through sign in and answer with cited evidence.
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Reviewed by: Arkangel AI clinical review team, Medical AI content
EBM step by step, and where AI helps
EBM is usually taught as five steps. The slow ones are searching and appraising: that is where AI saves time. The decisions stay with you.
1. Ask: turn the case into a PICO question
PICO stands for Patient or problem, Intervention, Comparison and Outcome. AI can draft the question from your case; check that each component matches your patient before searching.
- Example: in adults with non-valvular atrial fibrillation (P), do direct oral anticoagulants (I) compared with warfarin (C) reduce stroke and major bleeding (O)?
2. Acquire: find the best available evidence
AI searches studies and guidelines and links every source it cites. Open the sources: a citation is only useful if it says what the answer claims.
3. Appraise: judge validity and certainty
Review risk of bias, internal validity and applicability. GRADE rates the certainty of a body of evidence as high, moderate, low or very low; AI can explain which factors lower or raise it, and you decide whether you agree.
4. Apply: combine evidence with the patient
AI does not know your patient. Integrating the evidence with clinical context, preferences and available resources is your clinical judgment.
5. Assess: review the outcome and update
After acting, check whether the result matched what you expected, and repeat the search when new evidence or guidelines appear.
Limits and safe use
AI answers can be incomplete or wrong, so verify every cited source before acting. On self-serve plans, do not include information that identifies the patient.
How it supports EBM
Ask, acquire, appraise, apply — the full EBM cycle.
Frame and acquire
Turn a clinical scenario into a focused PICO question and acquire the best available evidence to answer it, with sources kept in view.
Critically appraise
Assess a study's risk of bias, validity and applicability, and identify the methodological limitations that affect how far you can trust it.
Rate certainty with GRADE
Judge the certainty of evidence for a recommendation using GRADE, accounting for risk of bias, inconsistency, imprecision and more.
Evidence-based search built for clinicians
Ask any clinical question and get a concise, cited answer drawn from peer-reviewed literature and clinical guidelines.
Explore potential documentation gaps
Review available, supported records for potential billing details and documentation gaps. Validate findings against the complete clinical context.
Evidence at your fingertips
Explore available clinical guidelines and literature, and check the sources and relevance of each finding before applying it.
Findings for clinical review
Surface potential clinical risks and documentation gaps in supported records for professional review. Timing and coverage depend on the configured workflow.
Review potential billing gaps
Identify possible missing charges or coding gaps in supported records. Billing professionals validate the documentation and applicable payer rules before making changes.
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Role-based access control, secure development policies, and system change procedures let your team collaborate safely. Scale across departments with audit trails, asset handling controls, and subprocessors like Azure for anonymization—all documented in our public Compliance Center.
Book a demoFrequently asked questions
How is this different from evidence retrieval?
Beyond finding evidence, it supports the EBM method itself: forming the question, appraising study quality, and rating certainty before you apply it.
Does it use GRADE?
Yes. It assesses the certainty of evidence using the GRADE framework, explaining what raises or lowers confidence in a recommendation.
Can it critically appraise a study?
Yes. It walks through risk of bias, internal validity and applicability for a given trial, helping you judge how much weight it deserves.
Is it free?
Arkangel AI has a free plan with limited searches. Paid plans raise the usage limits.
What are the five steps of evidence-based medicine?
Ask a focused clinical question (often in PICO format), acquire the best available evidence, appraise its validity and certainty, apply it together with clinical expertise and patient values, and assess the outcome.
Compare Arkangel AI with other clinical tools
Clinical decision support, not a replacement
Arkangel AI supports clinical decision-making and does not replace clinician judgment. Always confirm recommendations against primary sources and your local protocols before acting.